Writing a CAM Grant: Challenges in Clinical Trial Design and Important Statistical Considerations

Thank you for signing up for our workshop, "Writing a CAM Grant: Challenges in Clinical Trial Design and Important Statistical Considerations" being held on Tuesday May 15 at the Integrative Medicine and Health conference in Portland, OR. We are attaching links to four articles that we will be using in our workshop. During the workshop, we will divide you into small groups and ask you to review one of these research papers. You will then be asked to visualize what an extension to this published research that might be the basis for a grant proposal. You will have time to read during the small group exercises, but if you do a quick review in advance, you should be able to get more out of this small group exercise. Do not feel that you need to read the entire article in detail.  Just spend five minutes getting familiar with each article and try to think about which article appeals to you the most. If you do not get a chance to review these articles in advance, do not worry. 
 
Here are the questions we want workshop participants to address during the small group exercise.
 
  1. Read the abstract of this research paper and define the primary research hypothesis. If there is more than one research hypothesis, select the hypothesis of greatest interest to you. Be sure to specify the patient population, the intervention, the comparison group, and the outcome variable.
  2. Visualize an extension to this research hypothesis that you would like to seek funding for. Do not make it a straight up replication, but do not go too far afield either. Briefly describe the changes you propose in your extension. Your changes might involve a different patient population, a revised intervention, a new control group, a different outcome measure, some combination of the above, or possibly a change different than the ones proposed here. Explain why you proposed these changes. Was it to correct for a methodological weakness in the existing study or to broaden the applicability of this research finding or for some other reason?
  3. For your proposed extension, explain what sort of pilot study you might you consider as part of your grant proposal. What information would that pilot study provide you?
  4. Would randomization be appropriate for a large scale trial examining your extension? What are the potential problems with randomization?
  5. What type of blinding or partial blinding would you propose in the grant studying your extension? If a fully blinded study is not possible, explain why. What are some ways that attempts at blinding might fail for your extension?

 

 

Please read the following articles in preparation for the Workshop.  

 

 

 

 

PDF Downloads

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